Bioequivalence of Alprazolam Sublingual Tablet Formulation and Alprazolam Immediate Release Tablet in Healthy Volunteers
نویسندگان
چکیده
Alprazolam immediate release (IR) tablets are currently approved for the management of anxiety disorder or the short-term relief of symptoms of anxiety. A sublingual (SL) formulation of alprazolam, which disintegrates in the mouth without the need for additional fluids, has been developed. The aim of this study was to determine if the alprazolam SL 1 mg tablet was bioequivalent to the alprazolam IR 1 mg tablet in healthy volunteers.
منابع مشابه
Absence of food effect on the extent of alprazolam absorption from an orally disintegrating tablet.
STUDY OBJECTIVE To evaluate the effect of a standardized meal on the bioavailability of alprazolam formulated as an immediate-release orally disintegrating tablet (ODT) in healthy volunteers. DESIGN Single-dose, randomized, open-label, two-period crossover study. SETTING Contract research organization clinic. SUBJECTS Sixteen healthy volunteers (seven men, nine women), aged 20-50 years. I...
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